Wednesday, December 24, 2008

Evidence of State Interference with Computer 3 (March 10, 2008)

cut and paste‏
From: cam huegenot (cameocares@live.com)
Sent: Mon 3/10/08 2:32 PM
To: cameocares@live.com
Still can't cut and paste, even though no one is on their computer at the reception front desk. My cut and paste is disabled. I've tried several times with a witness watching.

http://answers.google.com/answers/threadview?id=147467

used the edit button to finally cut and paste the address above. Then, tried to copy from edit button the text below, and the button wouldn't work and didn't give me paste options. The woman next to me stood up and looked over my shoulder and when I tried again, it finally worked and I successfully pasted what is below.


Hello idoldgal

An article published in 1998 in the journal Pain, Volume 76 (pages
3-8) by Ethan Russo MD “Cannabis for Migraine Treatment: The Once and
Future Prescription” (available at
http://www.ardpark.org/research/migraine.htm , web site of the
Arkansas Alliance for Medical Marijuana), argues for the need for
controlled clinical trials to assess the efficacy of cannabis in the
treatment of migraine. Here follows a summary:
Russo reviews the medical use of marijuana from ancient times. In the
second half of the nineteenth century, it was considered to be a
valuable therapy for headache.
Russo writes: “Proponents included Weir Mitchell in 1874, E.J. Waring
in 1874, Hobart Hare in 1887, Sir William Gowers in 1888, J.R.
Reynolds in 1890, J.B. Mattison in 1891, et al., (Walton, 1938;
Mikuriya, 1969). Cannabis was included in the mainstream pharmacopeias
in Britain and America for this indication. As late as 1915, Sir
William Osler, the acknowledged father of modern medicine, stated of
migraine treatment (Osler, 1915), "Cannabis indica is probably the
most satisfactory remedy. Seguin recommended a prolonged course." This
statement supports its use for both acute and prophylactic treatment
of migraine.”
Marijuana became illegal in the USA in 1937, although the American
Medical Association, according to Russo, declared its opposition to
this. In 1938, Robert Walton published a review on the therapeutic
use of marijuana for migraine, and cited 12 major authorities who
considered it to be useful, as opposed to one who did not. “In 1941,
Cannabis preparations were dropped from the United States Pharmacopeia
(U.S.P.), but the following year, the editor of the Journal of the
American Medical Association still advocated oral preparations of
Cannabis in treatment of menstrual (catamenial) migraine (Fishbein,
1942). This practitioner seemed to prefer Cannabis to ergotamine
tartrate, which remains in the migraine armamentarium, some fifty-five
years later.”
In 1974, an article appeared which “examined five case studies of
patients who volitionally experimented with the substance to treat
painful conditions. Three had chronic headaches, and found relief by
smoking Cannabis that was comparable, or superior to ergotamine
tartrate and aspirin.” Russo cites an article entitled "Marijuana
and Migraine" (El-Mallakh, 1987: published in Headache Volume 27(8):
pp 442-443 ),which “presented three cases in which abrupt cessation of
frequent, prolonged, daily marijuana smoking were followed by migraine
attacks. One patient noted subsequent remission of headaches with
episodic marijuana use, while conventional drugs successfully treated
the others. The author hypothesized that THC's peripheral
vasoconstrictive actions in rats, or its action to minimize serotonin
release from the platelets of human migraineurs (Volfe et al., 1985),
might explain its actions.” [You can find the summary of the Volfe
article at http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2997048&dopt=Abstract
The article was published in the International Journal of Clinical
Pharmacological Research, Volum 5: pp. 243-246 “Cannabinoids block
release of serotonin from platelets induced by plasma from migraine
patients.” by Volfe Z, Dvilansky A, Nathan I.]
Russo then goes on to describe some of the brain chemistry which might
account for cannabis having an effect on migraine, and then comments
“The understanding that Cannabis and THC effect their actions through
natural cerebral biochemical processes has intensified the public
debate on medical benefits of marijuana. In 1993, a book entitled
Marihuana: The Forbidden Medicine (Grinspoon and Bakalar, 1993)
examined a variety of claims for ailments treated by marijuana, and
included an entire section on migraine. One clinical vignette
discussed at length the medical odyssey of a migraineur through
failures with standard pharmaceuticals, and ultimate preference for
small doses of smoked marijuana for symptom control.” He says: “The
author believes that the issue of medical marijuana, and its possible
role in migraine treatment deserves proper scientific examination,
both biochemically and clinically.”

In 1973, Tod H. Mikuriya, M.D edited a book which reproduces papers on
the medical use of marijuana published in the period 1839-1972. You
can see the list of papers, plus the introduction to the book at
http://www.pdxnorml.org/Dr_Mikuriya.html
These include: Reynolds, J. Russell: Therapeutical uses and toxic
effects of cannabis indica, Lancet, 1:637-38, 22 Mar. 1890. “Reynolds,
in 1890, 33 summed up thirty years of his clinical experience using
cannabis, finding it useful as a nocturnal sedative in senile
insomnia, and valuable in treating dysmenorrhea, neuralgias including
tic douloureux and tabetic symptoms, migraine headache and certain
epileptoid or choreoid muscle spasms.”
Osler, W., and McCrae, T.: Principles and Practice of Medicine, 8th
Edition, D. Appleton and Co., New York, 1916, p. 1089. “Concerning
migraine headache, Osler stated in his text: Cannabis indica is
probably the most satisfactory remedy.”

Since much of the above is anecdotal evidence describing individual
cases, Ethan Russo made an application to the FDA to conduct a study
of the use of marijuana in migraine patients. After several
unsuccessful attempts, the FDA in October 1999 approved a proposal to
study “the effects of smoked cannabis (marijuana) as compared to oral
dronabinol (Marinol) and injected sumatriptan. The study will enroll
40 patients with severe migraine” However, in February 2000, the PHS
refused to supply Russo with marijuana for this study, citing flaws in
the study. A copy of the PHS letter is available at
http://www.maps.org/mmj/russo1199/02010001.html and the whole story
of Russo’s efforts to get the study underway is summarised here:
http://www.maps.org/mmj/mjrusso.html

I have not been able to find any further information on whether this
study has now commenced. However, I did find an in-depth review by
Russo, “Hemp for headaches”, published in 2001 in Journal of Cannabis
Therapeutics, Vol. 1. In it he argues onc more for the need for
clinical trials and says: “This author’s personal experience in
communicating with several hundred migraineurs who have employed
cannabis is that 80% havenoted improvement, often with complete
symptomatic relief. That this has occurred without any quality control
of the herb whatsoever is most compelling.”
The full text of the review (72 pages) is available at
http://www.freedomtoexhale.com/hh.pdf

Search strategy: 1. marijuana. migraine 2. “Ethan Russo” The
searches were carried out on Google and on the Medline database of
medical journal literature at
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi

idoldgal-ga rated this answer:4 out of 5 stars

Excellent answer. I especially appreciate the links to the various
reference materials. That will allow me to explore the subject
further and at my own leisure. Thank you very much. idoldgal

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